The development of multiple sclerosis lesions appear as different contrast mechanisms on the different MR imaging scans. In T1 weighted images, these evolve into hypointense lesions and representative of demyelination. In this study, we propose a method of quantifying T1 values using retrospective data of T1 weighted images, and apply this method to investigate potential trends of T1 changes in multiple sclerosis patients across time. We look at four patients imaged at three time points across 12 months, and find that an increase in T1 of lesions may be a trend.
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