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Abstract #2431

Microstructural alterations in patients after liver transplantation and treated with calcineurin inhibitors – a quantitative MRI study

Lukas Goede1, Birte Schmitz1, Henning Pflugrad2, Anita Blanka Tryc2, Hannelore Barg-Hock3, Jürgen Klempnauer3, Karin Weissenborn2, Heinrich Lanfermann1, and Xiao-Qi Ding1

1Institute for Neuroradiology, Hannover Medical School, Hannover, Germany, 2Department of Neurology, Hannover Medical School, Hannover, Germany, 3Clinic for Visceral and Transplant Surgery, Hannover Medical School, Hannover, Germany

With the aim to evaluate possible brain microstructural alterations associated with calcineurin inhibitor (CNI) therapy, ninety patients after liver transplantation (OLT) treated with different doses of CNI and 32 gender- and age-adjusted healthy volunteers were studied with quantitative MRI (qMRI). T1, T2, T2*, Proton density (PD) and phase changes (derived from susceptibility-weighted imaging, SWI) were measured in 18 brain regions (regions of interest, ROIs). The values were compared between the groups of patients and the controls, which showed significant differences between the groups, indicating alterations of brain microstructure in patients after OLT.

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