Abstract #2442

Excitatory Repetitive Transcranial Magnetic Stimulation (rTMS) Induces Contralesional Cortex-Cerebellar Pathways to Facilitate Motor Recovery after Acute Ischemic Stroke

Jing Li¹, Zhentao Zuo², Xuewei Zhang^1,3, Jie Lu¹, Xiali Shao¹, Rong Xue², Yong Fan⁴, Yuzhou Guan⁵, and Weihong Zhang¹

¹Department of Radiology, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing, People's Republic of China, ²State Key Laboratory of Brain and Cognitive Science, Beijing MR Center for Brain Research, Institute of Biophysics, Chinese Academy of Sciences, Beijing, People's Republic of China, ³Department of Interventional Radiology, China Meitan General Hospital, Beijing, People's Republic of China, ⁴Department of Radiology, Department of Radiology, School of Medicine, University of Pennsylvania, Philadelphia, PA, United States, ⁵Department of Neurology, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing, People's Republic of China

In this study we used the Diffusion Tensor Imaging method to assess motor pathway changes in acute ischemic stroke patients after high frequency repetitive transcranial magnetic stimulation (rTMS). We found that the excitatory rTMS applied to the ipsilesional primary motor cortex induced the contralesional cortex-cerebellar loop to facilitate motor recovery. The result is consistent with those of our former studies and gives us a clue to understand the therapeutic mechanism of rTMS for early stroke patients.

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