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Abstract #2443

Detection of cerebral microvascular lesions using 7 T MRI in patients with neuropsychiatric systemic lupus erythematosus

yuka oikawa1, okinori murata2, nobuhito sasaki2, ami matsumoto2, akihiro ootsu2, yutaka nakamura2, yukari ninomiya2, makoto sasaki3, and kohei yamauchi2

1Division of Pulmonary Medicine,Allergy,and Rhematology,Department of internal Medicine, Iwate Medical University, morioka, Japan, 2Pulmonary Medicine,Allergy,and Rheumatology, Iwate Medical University, Morioka, Japan, 3Ultra-High Field MRI and Department of Radiology, Iwate Medical University, morioka, Japan

We investigated whether high-resolution images obtained using ultrahigh field MRI at 7 T can detect microcerebrovascular lesions in patients with neuropsychiatric systemic lupus erythematosus (NPSLE) that have never been detected by conventional MRI. We prospectively examined 20 patients with SLE, including five with NPSLE, using a 7 T MRI scanner. On the high-resolution T1WIs obtained at 7 T, minute punctate/linear hyperintense lesions in subcortical and/or cortical areas were found in four (80%) NPSLE patients and one (7%) non-NPSLE patient. High-resolution T1WIs obtained at 7 T can detect minute lesions, indicating intracerebral microvascular lesions in patients with NPSLE.

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