Meeting Banner
Abstract #2460

Reduced cortical thickness in patients with sickle cell disease and a high pain burden: baseline results from the Prevention of Morbidity in Sickle Cell Anaemia trial

Jamie M Kawadler1, Christina Liossi2, Chris A Clark1, and Fenella J Kirkham1

1Developmental Neurosciences, UCL Great Ormond Street Institute of Child Health, London, United Kingdom, 2School of Psychology, University of Southampton, Highfield, United Kingdom

Although acute vaso-occlusive pain crises are common in sickle cell disease (SCD), some patients also experience chronic daily pain. This study investigated cortical areas involved in pain processing in low-pain and high-pain groups of patients at baseline of a trial with a pain burden outcome. High-pain patients had significantly thinner cortex in the right anterior cingulate cortex, bilateral posterior cingulate cortex, bilateral precuneus and left primary motor cortex. This is the first study showing structural brain abnormalities in patients with SCD and a high pain burden; these data may provide potential biomarkers for longitudinal trials of treatment for chronic pain.

This abstract and the presentation materials are available to members only; a login is required.

Join Here