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Abstract #2461

White matter volume change of carbon monoxide intoxication: a 9-month follow-up study

Meng-Hsin Lee1, Tzu-Chao Chuang1, Hsiao-Wen Chung2, Jie-Yuan Li3, and Ping-Hong Lai4

1Electrical Engineering, National Sun Yat-Sen University, Kaohsiung, Taiwan, 2Electrical Engineering, National Taiwan University, 3Neurology, E-Da Hospital, 4Radiology, Kaohsiung Veterans General Hospital

Using automated segmentation, volume of brain tissues is assessed at around one week, one month, three months, and 9 months after CO exposure. Among all 17 patients (7 male, mean age: 42.7 yr) recruited in this prospective study, seven are diagnosed with delayed neuropsychiatric syndrome (DNS) and the other ten without. Our results indicate that the white matter volume of all DNS positive patients shows similar trends that it first increases at 1-month follow-up and then decreases, when other GM tissues remain the same. In addition, no volume change is observed in the group without DNS.

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