Abstract #2465

Assessment of cerebral perfusion autoregulation impairment – An experimental setup to quantify regional cerebral blood flow (CBF) in normal and head down tilt position

Dhaval B Shah¹, Michael G Dwyer¹, Brian Koyn², Nicola Bertolino¹, Cheryl Knapp³, Barry S Willer⁴, John J Leddy⁵, Robert Zivadinov^1,3, and Ferdinand Schweser^1,3

¹Buffalo Neuroimaging Analysis Center, Department of Neurology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, The State University of New York, Buffalo, NY, United States, ²Health Sciences Fabrication Shop, Department of Medicine,Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, The State University of New York, Buffalo, NY, United States, ³MRI Clinical and Translational Research Center, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, The State University of New York, Buffalo, NY, United States, ⁴Department of Psychiatry,Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, The State University of New York, Buffalo, NY, United States, ⁵Department of Orthopedics,Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, The State University of New York, Buffalo, NY, United States

Previous studies using Transcranial Doppler have shown that cerebral ischemia, head trauma, and cerebral perfusion pressure are associated with an impairment of the cerebral autoregulation (CA) and alteration of perfusion. However, simulating perfusion changes and quantifying them with higher specificity repetitively has been a challenge in clinics. We propose a clinical experimental setup for an MRI-based head down tilt protocol to study the CA by quantifying perfusion. We demonstrate local perfusion change results in healthy controls and a patient.

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