Abstract #2477

Environmental paraquat exposure and HFE genetics as factors in the development of Parkinson’s disease

Mark D Meadowcroft^1,2, Carson J Purnell¹, Douglas G Peters³, Qing X Yang², and James R Connor¹

¹Neurosurgery, The Pennsylvania State University - College of Medicine, Hershey, PA, United States, ²Radiology, The Pennsylvania State University - College of Medicine, Hershey, PA, United States, ³Neural and Behavioral Sciences, The Pennsylvania State University - College of Medicine, Hershey, PA, United States

This work demonstrates a decrease in R2 within the ventral-nigral region of WT-HFE mice given paraquat injections. Furthermore, the decrease in R2 relaxation rate is not observed in the H67D-HFE mutation animals. This is the first demonstration that HFE mutations may be associated with a preservation of cellular loss in the substantia nigra and ventral-midbrain of Parkinson’s disease model animals.

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