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Abstract #2478

Effects of myelin changes in Parkinson's Disease on motor performance

Tobias R Baumeister1,2, Sun Nee Tan2,3, and Martin J McKeown2,4

1Department of Biomedical Engineering, University of British Columbia, Vancouver, BC, Canada, 2Pacific Pakinson's Research Centre, UBC Hospital, Vancouver, BC, Canada, 3Graduate Program in Neuroscience, University of British Columbia, 4Faculty of Medicine, Neurology, University of British Columbia, Vancouver, BC, Canada

Parkinson’s Disease is not normally associated with white matter changes in clinical MRI scans. Myelin water imaging was used to probe the white matter tissue integrity of mildly affected Parkinson’s Disease patients. Partial Least Squares regression was employed to find a multivariate relation between myelin water fraction along different white matter tracts and motor performance scores. We found association between myelin water fraction and rigidity, bradykinesia and tremor scores, linking changes in white matter tissue integrity to Parkinson’s Disease severity in motor scores.

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