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Abstract #2479

The Correlation Between Brain Iron Overload and Microstructure Change in Gray Matter Nucleus in Parkinson' s Disease

bingbing gao1, bing wu2, liang han3, jing jing3, and yanwei miao3

1first affiliated hospital of DaLian medical univercity, Da Lian, People's Republic of China, 2GE healthcare, People's Republic of China, 3first affiliated hospital of DaLian medical univercity, People's Republic of China

Enhanced Gradient Echo T2 Star Weighted Angiography (ESWAN) can sensitively shows iron overload in brain, especially gray matter; Diffusion Kurtosis Imaging (DKI) detects microstructure change of gray matter much better than Diffusion Tensor Imaging (DTI). PD patients has the iron overload in substantia nigra, and encephalatrophy on different levels--cortex, basal ganglia and midbrain. To emplore the relation between iron overload and microstructure change in extrapyramidal nuclei, we compared DKI and ESWAN parameters in PD and healthy control groups, and analysis the correlation between them. Found that there are some relations in substantia nigra, red nucleus and putamen in PD patients.

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