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Abstract #2483

Functional connectivity depending on duration of parkinsonism before diagnosis of mild cognitive impairment in Parkinson Disease: focusing on the substantia innominata.

Na-Young Shin1, Injoong Kim2, Yunjin Bak1, Phil Hyu Lee3, Seung-Koo Lee4, and Soo Mee Lim5

1Department of Radiology, Ewha Womans University School of Medicine, Seoul, Korea, Republic of, 2Department of Radiology, Veterans Health Service Medical Center, 3Department of Neurology, Yonsei University College of Medicine, 4Department of Radiology, Yonsei University College of Medicine, 5Department of Radiology, Ewha Womans University School of Medicine

Degenerative change in the nucleus basalis of Meynert, a group of cholinergic neurons in the substantia innominata (SI) of the basal forebrain, begins in the early stages of Parkinson disease (PD) and is known to be significantly correlated with cognitive performance. We found decreased resting state functional connectivity (rsFC) in bilateral frontal areas using bilateral SI mask as a seed and significant correlation between decreased rsFC and shorter disease duration before mild cognitive impairment was diagnosed in patients with Parkinson’s disease. Therefore, our results support that cholinergic deficit plays an important role in the acceleration of cognitive decline and conversion to PD dementia.

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