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Abstract #2491

Altered Functional Connectivity Density in Subtypes of Parkinson’s Disease: a Resting-State fMRI Study

Xiaofei Hu1, Yuchao Jiang2, Xiaoyue Zhou3, Cheng Luo2, and Jian Wang1

1Department of Radiology, Southwest Hospital, Third Military Medical University, Chongqing, 400038, P.R. China, Chongqing, People's Republic of China, 2Key Laboratory for Neuro Information of Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China (UESTC), Chengdu, 610054, P.R. China, People's Republic of China, 3Collaboration NEA, Siemens Healthcare Ltd., Shanghai, P.R. China, People's Republic of China

In the current study, combined functional connectivity density (FCD) and seed-based FC analyses were performed to fully characterize the abnormal brain networks in the two subtypes. Our findings obtained using a combination of FCD and seed-based FC analyses provide consistent evidence for that the network disorganization of the brains in the two PD subtypes were different.We also found that the FCD provided good discrimination between the AR and TD patients. These findings have important implications for understanding the neural substrates that underlie these disparate manifestations of PD.

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