In the current study, combined functional connectivity density (FCD) and seed-based FC analyses were performed to fully characterize the abnormal brain networks in the two subtypes. Our findings obtained using a combination of FCD and seed-based FC analyses provide consistent evidence for that the network disorganization of the brains in the two PD subtypes were different.We also found that the FCD provided good discrimination between the AR and TD patients. These findings have important implications for understanding the neural substrates that underlie these disparate manifestations of PD.
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