We try to find out the longitudinal volume change of different hippocampal subfields in patients with PD with and without cognitive decline using magnetic resonance image (MRI). Our result shows that there is cross-sectional and longitudinal regional atrophy of specific hippocampal subfields in PD, which becomes more severe and is further extended to the bilateral CA2-3 and CA4-DG subfields in patients with cognitive decline. These results corroborate neuropathological findings and add novel information about the involvement of the hippocampus in the cognitive dysfunction of PD.
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