Abstract #2493

Comparison of MR spectroscopic imaging findings between different MAPT and COMT genotypes of cognitively normal or mild cognitively impaired Parkinson’s disease patients at 3T

Sevim Cengiz¹, Ani Kicik^2,3, Emel Erdogdu⁴, Dilek Betul Arslan¹, Seda Buker⁵, Zeynep Tufekcioglu⁵, Aziz Mufit Ulug^1,6, Basar Bilgic⁵, Hakan Gurvit⁵, Tamer Demiralp^2,7, Erdem Tuzun⁸, Hasmet Hanagasi⁵, and Esin Ozturk-Isik¹

¹Institute of Biomedical Engineering, Bogazici University, Istanbul, Turkey, ²Hulusi Behcet Life Sciences Research Laboratory, Istanbul University, Istanbul, Turkey, ³Istanbul University, Institute of Experimental Medicine, Department of Neuroscience, Istanbul, Turkey, ⁴Institute of Psychology and Cognition Research, University of Bremen, Germany, ⁵Department of Neurology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey, ⁶CorTechs Labs, San Diego, CA, USA, ⁷Department of Physiology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey, ⁸Institute of Experimental Medicine, Istanbul University, Istanbul, Turkey

Microtubule-associated protein tau (MAPT) and catechol-O-methyltransferase (COMT) genotypes have been associated with cognitive impairment in Parkinson’s disease (PD). The aim of this study is to compare MR spectroscopic imaging findings between cognitively normal PD (PD-CN) or mild cognitively impaired PD (PD-MCI) patients with different MAPT and COMT genotypes at 3T. We observed a higher Ins/Cr in cerebral white matter of PD-MCI with MAPT H1/H2 genotype than PD-CN with MAPT H1/H1 genotype and a higher Cho/Cr in thalamus of PD-MCI with COMT Met/Met genotype and PD-CN with COMT Val/Val or Val/Met genotype than PD-CN with COMT Met/Met genotype.

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