Abstract #2494

Preliminary findings of elevated iron deposition in the substantia nigra in patients with idiopathic Parkinson’s disease using a high iron content evaluation of quantitative susceptibility mapping

Sean K Sethi¹, Shawn Kisch², Kiarash Ghassaban¹, Saifeng Liu³, Miller Fawaz¹, Ali H. Rajput⁴, Alex Rajput⁴, Paul Babyn⁵, Peter Szkup⁵, and E. Mark Haacke^1,3,6

¹Research, Magnetic Resonance Innovations, Inc., Detroit, MI, United States, ²Department of Medical Imaging, Saskatoon Health Region, ³Research, The MRI Institute for Biomedical Research, Detroit, MI, United States, ⁴Division of Neurology in the Department of Medicine, University of Saskatchewan, ⁵Department of Medical Imaging, University of Saskatchewan, Saskatoon, SK, ⁶Radiology, Wayne State University School of Medicine

Iron deposition in the brain has been implicated in neurodegenerative diseases like Parkinson’s Disease. We used quantitative susceptibility mapping to evaluate iron content in the substantia nigra and red nucleus in 18 patients with idiopathic Parkinson’s Disease (IPD). Susceptibility was calculated for whole structure and a thresholded high-iron region (RII) and compared with controls. We found that global and RII mean susceptibility higher in the substantia nigra compared with normals, and that the slope of RII susceptibility vs age is higher in IPD compared to normals which may suggest an increased rate of iron deposition at disease onset.

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