Huntington’s Disease (HD) is a neurodegenerative disease would result in atrophy in basal ganglia especially in caudate nucleus and putamen in the early stage of the disease. The cortical parcellation algorithm was applied to evaluate the cortical involvement in the patients with HD by using diffusion MRI and compared with voxel based morphometry. The mean diffusivity is feasible in the brain of patients with HD, which is more sensitive than the morphometric changes. Therefore mean diffusivity could be a potential image based biomarker for monitoring HD progression.
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