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Abstract #2497

Extensive cortical involvement in patients with Huntington’s Disease as measured from diffusion MRI

Jung-Sen Hsiao1, Sung-han Lin1, Chih-Chien Tsai1, Chiung-Mei Chen2, and Jiun-Jie Wang1,3

1Medical Imaging and Radiological Sciences, Chang-Gung University, Taoyuan City, Taiwan, 2Neurology, Chang Gung Memorial Hospital, Linkou, Taoyuan City, Taiwan, 3Neuroscience Research Center, Chang Gung Memorial Hospital, Linkou, Taoyuan City, Taiwan

Huntington’s Disease (HD) is a neurodegenerative disease would result in atrophy in basal ganglia especially in caudate nucleus and putamen in the early stage of the disease. The cortical parcellation algorithm was applied to evaluate the cortical involvement in the patients with HD by using diffusion MRI and compared with voxel based morphometry. The mean diffusivity is feasible in the brain of patients with HD, which is more sensitive than the morphometric changes. Therefore mean diffusivity could be a potential image based biomarker for monitoring HD progression.

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