Abstract #2498

Functional connectivity disturbances in prodromal Huntington’s disease predict future cognitive decline

Katherine A Koenig¹, Jian Lin¹, Mark Lowe¹, Stephen Rao², Mourany Lyla², Deborah Harrington^3,4, Jane Paulson for the PREDICT-HD investigators of HSG⁵, and Sally Durgerian⁶

¹Imaging Institute, The Cleveland Clinic, Cleveland, OH, United States, ²Lou Ruvo Center for Brain Health, The Cleveland Clinic, Cleveland, OH, United States, ³Department of Radiology, University of California, San Diego, La Jolla, CA, United States, ⁴Research Service, VA San Diego Healthcare System, San Diego, CA, United States, ⁵Carver College of Medicine, The University of Iowa, Iowa City, IA, United States, ⁶BrainDataDriven, Milwaukee, WI, United States

This study investigates intrinsic functional connectivity of the dorsal caudate in prodromal Huntington’s disease participants. We find that connectivity to the left caudate increases as estimated time to a manifest diagnosis decreases, and that stronger connectivity between the right middle frontal gyrus and left caudate is predictive of future cognitive decline.

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