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Abstract #2498

Functional connectivity disturbances in prodromal Huntington’s disease predict future cognitive decline

Katherine A Koenig1, Jian Lin1, Mark Lowe1, Stephen Rao2, Mourany Lyla2, Deborah Harrington3,4, Jane Paulson for the PREDICT-HD investigators of HSG5, and Sally Durgerian6

1Imaging Institute, The Cleveland Clinic, Cleveland, OH, United States, 2Lou Ruvo Center for Brain Health, The Cleveland Clinic, Cleveland, OH, United States, 3Department of Radiology, University of California, San Diego, La Jolla, CA, United States, 4Research Service, VA San Diego Healthcare System, San Diego, CA, United States, 5Carver College of Medicine, The University of Iowa, Iowa City, IA, United States, 6BrainDataDriven, Milwaukee, WI, United States

This study investigates intrinsic functional connectivity of the dorsal caudate in prodromal Huntington’s disease participants. We find that connectivity to the left caudate increases as estimated time to a manifest diagnosis decreases, and that stronger connectivity between the right middle frontal gyrus and left caudate is predictive of future cognitive decline.

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