Abstract #2499

Deep grey matter T2 relaxometry at 3T in Huntington’s disease

Enrico De Vita^1,2, Sarah Gregory³, Lauren Byrne³, Filipe B Rodrigues³, Eileanoir Johnson³, Tarek Yousry^1,2, David Thomas², John S Thornton^1,2, and Edward J Wild³

¹Lysholm Department of Neuroradiology, National Hospital for Neurology and Neurosurgery. UCL Hospitals NHS Foundation Trust, London, United Kingdom, ²Academic Neuroradiological Unit. Department of Brain Repair and Rehabilitation, UCL Institute of Neurology, London, United Kingdom, ³Huntington's Disease Centre, UCL Institute of Neurology, London, United Kingdom

Iron levels in the basal ganglia in Huntington’s disease (HD) have been previously investigated at 3T with MRI using magnetic field correlation imaging, T2*, quantitative susceptibility mapping (QSM), as well as T2 relaxometry mostly at lower fields of 1.5T or less. We performed T2 mapping at 3T in a group of pre-HD (n=10) and HD patients (n=11) to investigate its association with Disease Burden Score and structural measures (caudate volume) of disease load. We found significant correlations between T2 and disease progression measures in nucleus accumbens, putamen and pallidum.

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