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Abstract #2500

Automated Volumetry-based Morphometry in Postural Instability Gait Disorder

Eric Fang*1, Chu Ning Ann*1, Bénédicte Maréchal2,3,4, Shawn Yan Zhi Tan1, Julian Gan 5, Huihua Li1, Eng King Tan 6, and Ling Ling Chan1

1Singapore General Hospital, Singapore, Singapore, 2Advanced Clinical Imaging Technology, Siemens Healthcare HC CEMEA SUI DI PI, Lausanne, Switzerland, 3Department of Radiology, University Hospital (CHUV), Lausanne, Switzerland, 4LTS5, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland, 5Advanced Clinical Imaging Technology, Siemens Healthcare HC CEMEA SUI DI PI, Singapore, Singapore, 6National Neuroscience Institute, Singapore

Postural instability gait disorder (PIGD) subtype in Parkinson's disease (PD) is a major cause of morbidity. We quantified whole-brain structural changes in PIGD patients, PD patients and controls using an automated volume-based morphometry algorithm that is objective and reproducible. Compared to PD and controls, PIGD subgroup demonstrated a significant decrease in brain and globus pallidus volume, as well as grey matter content in both caudate and thalamus; but an increase in ventricular size, abnormal white matter volume and relative caudate size. MRI findings also correlate with gait imbalance severity in PIGD, suggesting a mechanism of temporal differences in segmental volume loss.

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