Meeting Banner
Abstract #2501

Measuring exercise-induced cerebrovascular changes in Huntington's Disease using arterial spin labelling (ASL) fMRI

Jessica J Steventon1,2, Hannah Furby1, James Ralph1, Peter O'Callaghan3, Anne Rosser4, Monica Busse5, and Kevin Murphy6

1CUBRIC, Cardiff University, Cardiff, United Kingdom, 2Neuroscience and Mental Health Research Institute, Cardiff University, 3Cardiac Services, Cardiff and Vale University Health Board, Cardiff, United Kingdom, 4School of Medicine, Cardiff University, 5Centre for Trials Research, Cardiff University, Cardiff, United Kingdom, 6School of Physics and Astronomy, Cardiff University

Exercise is potentially therapeutic via vascular adaptations (angiogenesis, improved cerebral perfusion and metabolism) however the underlying dynamics are not fully understood. In Huntington´s disease (HD), where the therapeutic potential of exercise is being explored, cerebral vasculature alterations have been reported.

Here we used arterial spin labelling to examine the acute effect of aerobic exercise on the cerebrovasculature in HD patients. We show that genetic disease load is related to both baseline cerebral blood flow (CBF) and the exercise-induced change in CBF.

This abstract and the presentation materials are available to members only; a login is required.

Join Here