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Abstract #2502

Lessons for MRI recruitment in movement disorder: Clinical presentation is not related to motion artefacts in arterial spin labelling MRI

Jessica J Steventon1,2, Hannah Furby1, James Ralph1, Anne Rosser3, and Kevin Murphy4

1CUBRIC, Cardiff University, Cardiff, United Kingdom, 2Neuroscience and Mental Health Research Institute, Cardiff University, 3School of Medicine, Cardiff University, 4School of Physics and Astronomy, Cardiff University

Motion artefacts pose significant problems for the acquisition and analysis of MRI data. In movement disorders, severe motion-related artefacts can result in data being discarded as non-usable. It is not known to what degree clinical movement symptoms can predict in-scanner motion artefacts, and thus, whether researchers can target recruitment for MRI studies based on clinical presentation. Here we investigate whether movement severity in Huntington’s disease, a neurodegenerative movement disorder, can predict in-scanner motion artefacts in arterial spin labelling data. We find that motion magnitude and variability is not more pronounced in Huntington’s disease and not related to symptom severity.

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