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Abstract #2503

Cortical Recruitment of Motor Imagery in Timed Up and Go Task

Gina Kirkish1, Anisha Keshavan1, Nancy Byl2, William Stern1, Stacy Hatcher1, Tracy Luks3, and Roland Henry1,3

1Department of Neuology, University of California, San Francisco, San Fransisco, CA, United States, 2Department of Physical Therapy and Rehabilitation Science, University of California, San Francisco, 3Department of Radiology and Biomedical Imaging, University of California, San Francisco

A paradigm was developed to evaluate neural pathophysiology of gait and turning in individuals with Parkinson’s disease (PD) using fMRI. BOLD signal change of imagined walking and turning was compared to resting state activation in PD patients and controls. Subjects performed physical examinations including the Timed Up and Go (TUG) task, ten-meter walk and a timed 360-degree turn to assess motor performance. Brain activity was compared between groups and to motor performance. This study concluded that a neural correlate of the TUG task exists in BOLD signal change in the premotor and primary motor area when imagining-turning compared to imagining-walking.

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