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Abstract #2504

Benefits of high-resolution QSM acquisition protocol for DBS surgery planning

Alexey Dimov1,2, Yihao Yao3, Ilhami Kovanlikaya4, Pascal Spincemaille4, Jonathan Rasouli5, Brian Kopell5, and Yi Wang1,2

1Meing School of Biomedical Engineering, Cornell University, Ithaca, NY, United States, 2Radiology, Weill Cornell Medical College, New York, NY, United States, 3Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, People's Republic of China, 4Weill Cornell Medical College, New York, NY, United States, 5Department of Neurosurgery, Mount Sinai Health System, New York, NY, United States

Deep brain stimulation is a surgical procedure routinely used in the treatment of advanced stages of Parkinson disease. DBS involves implanting of stimulating electrodes inside the patient’s brain, with STN most commonly being the target brain structure. Treatment efficiency and absence of negative side effects is strongly dependent on precision of electrode placement; therefore, high requirements are imposed on preoperative patient imaging for proper identification of anatomy of interest. Histochemical studies suggest that iron (one of the major contrast contributors in QSM) is densely and heterogeneously distributed in STN. Furthermore, it is hypothesized that distribution of iron might be related to functional subdivisions in STN. Thus, DBS surgery planning might benefit from more precise calculation of susceptibility distribution, which would allow observe and characterize gradients in iron concentration in in vivo patient data potentially leading to minimization of non-motor side effects. Accordingly, we develop a high resolution QSM protocol for DBS presurgical MRI protocol.

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