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Abstract #2509

Toward Clinical Translation of Quantitative Spinal Cord MRI: Serial Monitoring to Identify Disease Progression in Patients with Degenerative Cervical Myelopathy

Allan R. Martin1, Benjamin De Leener2, Julien Cohen-Adad2, David W. Cadotte3, Jefferson R. Wilson1, Lindsay Tetreault1,4, Stefan F. Lange1, Aria Nouri1, Adrian Crawley5, David J. Mikulis5, Howard Ginsberg1, and Michael G. Fehlings1

1Neurosurgery, University of Toronto, Toronto, ON, Canada, 2Electrical Engineering, École Polytechnique de Montréal, 3Neurosurgery, University of Calgary, Calgary, AB, Canada, 4Medicine, University College Cork, Cork, Ireland, 5Medical Imaging, University of Toronto, Toronto, ON, Canada

Degenerative cervical myelopathy (DCM) is a common cause of disability, but mild patients are often managed non-operatively and monitored for deterioration. Popular clinical assessment tools are insensitive to detect subtle disease progression. In this study, we employ multi-parametric spinal cord MRI to monitor 15 DCM patients for progression over a 1-year period, in addition to a comprehensive battery of clinical assessments. The MRI results detected progressive tissue injury in 6/7 patients with definite clinical progression and 5 additional patients (4 of which had borderline clinical progression). These MRI assessments are now being incorporated into clinical practice to inform surgical decision-making.

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