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Abstract #2510

Reproducible fast T1 mapping of the human cervical spinal cord in vivo

Marco Battiston1, Torben Schneider2, Ferran Prados1,3, Francesco Grussu1, Marios C Yiannakas1, Sebastien Ourselin3, Claudia A M Gandini Wheeler-Kingshott1,4,5, and Rebecca S Samson1

1UCL Institute of Neurology, Queen Square MS Centre, UCL, London, United Kingdom, 2Philips Healthcare, Guilford, United Kingdom, 3Translational Imaging Group, Centre for Medical Image Computing, Department of Medical Physics and Biomedical Engineering, UCL, London, United Kingdom, 4Department of Brain and Behavioural Sciences, University of Pavia, Pavia, Italy, 5Brain MRI 3T Mondino Research Center, C. Mondino National Neurological Institute, Pavia, Italy

The T1 relaxation time is a fundamental quantitative Magnetic Resonance parameter widely used to characterize healthy and pathological tissue. However, quantitative T1 mapping in the human spinal cord (SC) has been limited to date, mainly due to its small size and sensitivity to artefacts. Here we assess the reproducibility of a time efficient (<5min) SC protocol for Inversion Recovery T1 mapping, which is considered the gold-standard method for T1 estimation. Scan-rescan experiments were performed in a cohort of 4 healthy subjects. High reproducibility (whole cord intraclass correlation=0.94) of T1 estimates was found, with whole cord intra-subject coefficient-of-variation<15% for all subjects.

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