Abstract #2511

Optimization of Quantitative Magnetization Transfer Imaging for Accurate PSR Estimation in the Spinal Cord

Robert L Harrigan^1,2, Bennett A Landman^1,2, and Seth A Smith^2,3

¹Department of Electrical Engineering, Vanderbilt University, Nashville, TN, United States, ²Vanderbilt University Institute of Imaging Science, Vanderbilt University, Nashville, TN, United States, ³Department of Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, TN, United States

Quantitative magnetization transfer (qMT) sampling schemes typically attempt uniform sampling of the MT z-spectrum but this may not be optimal for PSR estimation of the human spinal cord in vivo. We utilize Monté Carlo simulations of fitting synthetic qMT data to produce an optimal sampling scheme of the MT z-spectrum. This sampling scheme is evaluated in a healthy control and compared to current best practices where we see superior PSR estimation with our optimized sampling scheme.

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