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Abstract #2512

Application of Quantitative Microstructural MR Imaging with Atlas-based Analysis for Spinal Cord in Cervical Spondylotic Myelopathy.

Masaaki Hori1, Issei Fukunaga1, Ryo Ueda1,2, Kouhei Kamiya3, Yuichi Suzuki3, Katsutoshi Murata4, Tomohiro Takamura 1, Nozomi Hamasaki1, Ryusuke Irie1, Kanako Kunishima Kumamaru1, Michimasa Suzuki1, and Shigeki Aoki1

1Radiology, Juntendo University School of Medicine, Tokyo, Japan, 2Health Science, Tokyo Metropolitan University, Tokyo, Japan, 3Radiology, The University of Tokyo Hospital, Tokyo, Japan, 4Siemens Japan K.K., Tokyo, Japan

We investigated MR fiber g-ratio, AVF and MVF in evaluation of microstructural changes in the spinal cord in patients with cervical spondylotic myelopathy, with using atlas-based analysis by spinal cord tool box. 19 patients and 5 normal controls were included. MT-sat and NODDI data were collected at 3T MRI. The right side of fasciculus cuneatus and bilateral lateral corticospinal tracts (LSCT) of AVF were significant lower (P=0.014, 0.017, 0.014, one-way ANOVA with Scheffé’s post-hoc test) and the left LSCT of MVF was significant higher (P=0.037) in the affected side spinal cord, compared with normal controls.

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