Abstract #2512

Application of Quantitative Microstructural MR Imaging with Atlas-based Analysis for Spinal Cord in Cervical Spondylotic Myelopathy.

Masaaki Hori¹, Issei Fukunaga¹, Ryo Ueda^1,2, Kouhei Kamiya³, Yuichi Suzuki³, Katsutoshi Murata⁴, Tomohiro Takamura ¹, Nozomi Hamasaki¹, Ryusuke Irie¹, Kanako Kunishima Kumamaru¹, Michimasa Suzuki¹, and Shigeki Aoki¹

¹Radiology, Juntendo University School of Medicine, Tokyo, Japan, ²Health Science, Tokyo Metropolitan University, Tokyo, Japan, ³Radiology, The University of Tokyo Hospital, Tokyo, Japan, ⁴Siemens Japan K.K., Tokyo, Japan

We investigated MR fiber g-ratio, AVF and MVF in evaluation of microstructural changes in the spinal cord in patients with cervical spondylotic myelopathy, with using atlas-based analysis by spinal cord tool box. 19 patients and 5 normal controls were included. MT-sat and NODDI data were collected at 3T MRI. The right side of fasciculus cuneatus and bilateral lateral corticospinal tracts (LSCT) of AVF were significant lower (P=0.014, 0.017, 0.014, one-way ANOVA with Scheffé’s post-hoc test) and the left LSCT of MVF was significant higher (P=0.037) in the affected side spinal cord, compared with normal controls.

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