Abstract #2527

Iron is a biomarker for differentiating multiple sclerosis lesions from ischemic demyelinating lesions

Weiwei Chen¹, Yan Zhang¹, Ketao Mu¹, Susan A. Gauthier², Yi Wang^3,4, and Wenzhen Zhu¹

¹Tongji hospital, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, People's Republic of China, ²Neurology, Weill Cornell Medical College, NY, United States, ³Radiology, Weill Cornell Medical College, NY, United States, ⁴Department of Biomedical Engineering, Cornell University

Differentiation MS lesions from ischemic demyelinating lesions is important because of their totally different treatment strategies. Our results suggested that the increased susceptibility of demyelinating lesions, the presence of QSM-ring lesions and the central vein in the lesions helped to differentiate MS lesions from ischemic demyelinating lesions. Thus, QSM provided the underling iron-related pathogenesis of MS lesions, which enable to differentiate MS lesions from ischemic demyelinating lesions.

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