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Abstract #2544

Cortical Surface Magnetization Transfer Ratio Decreases in Multiple Sclerosis are Age and Region Dependent

David A. Rudko1, Josefina Maranzano1, Douglas L. Arnold1, and Sridar Narayanan1

1McConnell Brain Imaging Centre, Montreal Neurological Institute and Hospital, McGill University, Montreal, QC, Canada

Cortical pathology may be a substrate of worsening clinical symptoms in MS patients. However, the rate at which cortical pathology develops and the brain locations affected are not well known. The goal of this study was to evaluate longitudinal, age-related reductions in cortical surface magnetization transfer ratio (csMTR) of MS patients. Such reductions may be sensitive to sub-pial demyelination occurring over time.

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