Abstract #2545

The cerebello-thalamic tract as a neural correlate for tremor in MS

Frederique Maria Christina Boonstra¹, Grace Florescu², Scott Kolbe¹, Chris Steward³, Andrew Evans², Helmut Butzkueven², Peter Mitchell³, and Anneke Van Der Walt²

¹Melbourne Brain Centre, University of Melbourne, Melbourne, Australia, ²The Royal Melbourne Hospital, Melbourne, Australia, ³Radiology, Royal Melbourne Hospital, Melbourne, Australia

This study aims to determine the correlation between clinical tremor severity in Multiple Sclerosis (MS) and the cerebello-thalamic pathway. We found a decrease in volume of the ipsilateral Superior Cerebellar Peduncle and contralateral Thalamus. These regions of volume loss correlate with predicted neuro-anatomy indicating that the cerebello-thalamic pathway is a neural correlate of tremor severity in MS. This finding aids to a better understanding of pathogenesis and development of treatments for tremor in MS.

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