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Abstract #2545

The cerebello-thalamic tract as a neural correlate for tremor in MS

Frederique Maria Christina Boonstra1, Grace Florescu2, Scott Kolbe1, Chris Steward3, Andrew Evans2, Helmut Butzkueven2, Peter Mitchell3, and Anneke Van Der Walt2

1Melbourne Brain Centre, University of Melbourne, Melbourne, Australia, 2The Royal Melbourne Hospital, Melbourne, Australia, 3Radiology, Royal Melbourne Hospital, Melbourne, Australia

This study aims to determine the correlation between clinical tremor severity in Multiple Sclerosis (MS) and the cerebello-thalamic pathway. We found a decrease in volume of the ipsilateral Superior Cerebellar Peduncle and contralateral Thalamus. These regions of volume loss correlate with predicted neuro-anatomy indicating that the cerebello-thalamic pathway is a neural correlate of tremor severity in MS. This finding aids to a better understanding of pathogenesis and development of treatments for tremor in MS.

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