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Abstract #2546

New Enhancing and Chronic Multiple Sclerosis Lesions measured on Quantitative Susceptibility Mapping and Diffusion-Weighted Imaging

Yihao Yao1 and Yi Wang2,3

1Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, People's Republic of China, 2Department of Radiology, Weill Cornell Medical College, New York, NY, United States, 3Biomedical Engineering, Cornell University, Ithaca, NY, United States

QSM and DWI are sensitive to changes in MS lesions at various ages. We found chronic MS lesions had higher relative susceptibilities and lower relative ADC values as compared to new enhanced lesions. Combining QSM and ADC measurements could differentiate each two subtypes in four subtypes of lesions (nodular/shell enhanced lesions, rim+/- lesions). The pattern of QSM and ADC findings suggests that shell enhanced lesions have more demyelination than nodular enhanced lesions and rim- lesions. Combining QSM and ADC measurements might be a better way to differentiate MS lesions at various ages and provide more information of micro-changes of lesion.

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