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Abstract #2549

Rapid, high-resolution imaging of the central veins in multiple sclerosis at 1.5T, 3T, and 7T

Pascal Sati1, Sunil Patil2, Souheil I Inati3, Govind Nair1, Gunnar Krueger4, and Daniel S Reich1

1Translational Neuroradiology Section, NINDS, National Institutes of Health, Bethesda, MD, United States, 2Siemens Medical Solutions, HC NAM USA DI MR COLLAB, Bethesda, MD, United States, 3InatiAnalytics, Potomac, MD, United States, 4Siemens Medical Solutions, HC NAM USA DI MR COLLAB NE, Boston, MA, United States

The central vein sign (CVS) detected by magnetic resonance imaging (MRI) may aid with the diagnosis of multiple sclerosis (MS). The ability to detect central veins in the brain at any magnetic field strengths would open the pathway for future large-scale research studies, and potentially routine clinical use, of the CVS for MS diagnosis. In this study, a fast high-isotropic-resolution, whole-brain T2*-weighted segmented echo-planar-imaging acquisition was implemented at 1.5T, 3T and 7T. Central veins inside multiple sclerosis lesions were detected at all three different field strengths.

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