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Abstract #2553

Real Time MRI-guided convection-enhanced delivery in porcine brain to model multiple sclerosis by focal demyelination

Lukasz Kalkowski1, Izabela Malysz-Cymborska1, Dominika Golubczyk1, Miroslaw Janowski2,3,4, Piotr Holak5, Kamila Milewska1, Zbigniew Adamiak5, Joanna Wojtkiewicz6, Wojciech Maksymowicz1, Dorota Kedziorek2,3, and Piotr Walczak1,2,3

1Department of Neurology and Neurosurgery, University of Warmia and Mazury in Olsztyn, Olsztyn, Poland, 2Cellular Imaging Section and Vascular Biology Program, Institute for Cell Engineering, John Hopkins University, Baltimore, MD, United States, 3Russell H. Morgan Department of Radiology and Radiological Science, John Hopkins University, Baltimore, MD, United States, 4NeuroRepair Department, Mossakowski Medical Research Center, Polish Academy of Sciences, Warsaw, Poland, 5Department of Surgery and Roentgenology with the Clinic, University of Warmia and Mazury in Olsztyn, Olsztyn, Poland, 6Department of Pathophysiology, University of Warmia and Mazury in Olsztyn, Olsztyn, Poland

Modeling of multiple sclerosis is typically performed in rodents; however, due to several limitations large animal models are needed to improve clinical relevance. In this study we utilized MRI-guided convection enhanced delivery of gliotoxins (ethidium bromide and lysolecithin) to induce focal demyelination within corona radiata in pigs.

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