Meeting Banner
Abstract #2554

Quantitative Assessment of Limbic System Damage in Multiple Sclerosis

Jie Wen1, Dmitriy Yablonskiy1, and Anne Cross2

1Radiology, Washington University in St. Louis, St. Louis, MO, United States, 2Neurology, Washington University in St. Louis, St. Louis, MO, United States

The limbic system plays an important role in the emotion- and memory-related brain functions. In this study, we measured R2* and the volumes of the key elements of the limbic system and used them to detect abnormalities in the limbic system in multiple sclerosis (MS). The results showed significant differences between Secondary Progressive MS (SPMS) and healthy group. R2* of amygdala, thalamus, insula, lateral orbitofrontal and isthmus cingulate significantly correlate with clinical cognitive tests in female SPMS. Our results also showed that R2*-defined tissue alterations in the hippocampus and entorhinal cortex could identify depression behavior in MS patients.

This abstract and the presentation materials are available to members only; a login is required.

Join Here