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Abstract #2556

T1 Black Hole in Multiple Sclerosis: a reassessment of the specificity at 7T

Francesca Bagnato1, Assunta Dal-Bianco2, Richard Dortch1, Idan Kantor1, Bailey Lyttle1, Siddharama Pawate1, Lydia Mckeithan1, Bailey Box1, Simon Hemetner2, Hans Lassmann2, Brain Welch1, and Seth Smith1

1Vanderbilt University, Nashville, TN, United States, 2Medical University Vienna

7T imaging and the commensurate T1-lenghtening have the potential to increase lesion sensitivity at the expense of their specificity in patients with multiple sclerosis. In our work we demonstrate that (1) T1-hypontense lesions detected on T1-w MPRAGE reflect both remyelinated and chronic demyelinated lesions as measured by histology and that (2) associations between black hole lesion load and measures of physical and cognitive disability are weak. At 7T, the increased sensitivity to lesion penalizes the T1-w MPRAGE specificity to areas with higher water content and tissue destruction seen at lower field strength.

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