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Abstract #2557

Histological Validation of Diffusion Basis Spectrum Imaging Using Autopsied Multiple Sclerosis Brain Specimens

Ajit George1, Peng Sun2, Anne H Cross3, Xiaojie Wang4, Carlos J Pérez-Torres5, and Sheng-Kwei Song6

1Department of Radiology, Washington University, St. Louis, Saint Louis, MO, United States, 2Department of Radiology, Washington University, St. Louis, 3Department of Neurology, Washington University, St. Louis, MO, United States, 4Advanced Imaging Research Center, Oregon Health & Science University, OR, United States, 5Radiological Health Sciences, School of Health Sciences, Purdue University, West Lafayette, IN, United States, 6Department of Radiology, Washington University, St. Louis, MO, United States

In this study, we demonstrate diffusion basis spectrum imaging (DBSI) is able to detect, differentiate and quantify different coexisting pathologies, particularly axonal loss and demyelination within autopsied multiple sclerosis human brain specimens. We correlated the DBSI derived maps with quantitative histology maps generated by means of color based segmentation. DBSI-derived fiber fraction was seen to correlate with Bielschowsky’s silver stain for axonal integrity, and the DBSI-derived radial diffusivity negatively correlated with Luxol Fast Blue-Periodic Acid-Schiff (LFB-PAS) stain for myelin integrity.

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