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Abstract #2558

mcDESPOT-derived tissue parameters in the brainstem and corpus callosum of MS and NMOSD patients with cervical cord lesions

Lisa Eunyoung Lee1, Anna J.E Combes2, Jillian Chan1, Robert Carruthers1, Jacqueline Palace3, Lucy Matthews3, Anthony Traboulsee1, and Shannon Kolind1,4

1Department of Medicine, University of British Columbia, Vancouver, BC, Canada, 2Neuroimaging, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, United Kingdom, 3Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom, 4Department of Radiology, University of British Columbia, Vancouver, BC, Canada

Neuromyelitis optica spectrum disorder (NMOSD) and multiple sclerosis (MS) are demyelinating central nervous system disorders that may present with some overlapping clinical symptoms but differ pathophysiologically. We used tissue-specific quantitative measures, produced by mcDESPOT, to characterize tissue pathology in MS and NMOSD groups compared to healthy controls. We observed decreased myelin water fraction, increased T2 of intra/extracellular water, increased cerebrospinal volume fraction, and increased myelin water residence time in the brainstem and corpus callosum of MS and NMOSD subjects, compared to controls. These sensitive advanced MRI measures could provide an improved understanding of MS and NMOSD pathogenesis.

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