Abstract #2568

A Pseudo-Longitudinal Study of the Lifespan Neuroanatomical Changes based on a Large-scale Imaging Data

LIN SHI¹, PEIPENG LIANG^2,3,4, YISHAN LUO^3,4, KAI LIU³, Vincent CT MOK¹, Winnie CW CHU³, DEFENG WANG^3,4, and KUNCHENG LI²

¹Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, Hong Kong, ²Department of Radiology, Xuanwu Hospital, Capital Medical University, Beijing, People's Republic of China, ³Research Center for Medical Image Computing, Department of Imaging and Interventional Radiology, The Chinese University of Hong Kong, Hong Kong, Hong Kong, ⁴Shenzhen Research Institute, The Chinese University of Hong Kong, Shenzhen, People's Republic of China

Understanding how brain changes over the lifetime provides the basis for new insights into neurophysiology and neuropathology. In this study, we carried out a pseudo-longitudinal study based on large-scale cross-sectional high-resolution brain MR data atlas Chinese2020 to model the brain morphological changes in Han Chinese adulthood. Our results found some novel age-related neuroanatomical changes in a standardized brain space via temporal-spatial statistical brain templates.

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