Abstract #2569

Assessment of brain volume and shape abnormalities in chemotherapy-treated breast cancer survivors using voxel-based morphometry and vertex-wise shape analysis

TzyShyuan Ng¹, Vincent Chin-Hung Chen^2,3, Dah-Cherng Yeh⁴, Ren-Horng Wang¹, and Jun-Cheng Weng^1,5

¹Department of Medical Imaging and Radiological Sciences, Chung Shan Medical University, Taichung, Taiwan, ²School of Medicine, Chang Gung University, Taoyuan, Taiwan, ³Department of Psychiatry, Chang Gung Memorial Hospital, Chiayi, Taiwan, ⁴Breast Center, Taichung Tzu Chi Hospital, Taichung, Taiwan, ⁵Department of Medical Imaging, Chung Shan Medical University Hospital, Taichung, Taiwan

Cancer-related trauma after chemotherapy has been widely reported by breast cancer. The previous study consistently showed lower gray and white matter volume and density in patients treated with chemotherapy. The aim of this study was to find out the early effect in both brain volume and shape in the chemotherapy-treated breast cancer patients compared to healthy controls using voxel-based morphometry (VBM) and vertex-wise shape analyses, respectively. Our results showed significant changes in the brain structural volume and shape, particularly in the putamen and hippocampus.

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