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Abstract #2571

Mapping the Neurological Effect of Soman, a Chemical Warfare Nerve Agent, using 9.4T MRI

Kevin Lee1, Sara Bohnert2, Cory Vair2, Ying Wu1, John Mikler2, and Jeff Dunn1

1Radiology, University of Calgary, Calgary, AB, Canada, 2National Defence, Defence Research And Development Canada, Suffield, AB, Canada

Soman is a chemical warfare nerve agent that is categorized as a weapon of mass destruction. Nerve agents are potent irreversible inhibitors of acetylcholinesterase and exposure can be extremely lethal. At a sub-lethal dose, our understanding of the neurological effect is limited. To understand the soman associated physiological changes, MRI was used to quantify the cerebral blood flow after a convulsive dose of soman.

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