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Abstract #2583

The value of 7T in the clinical evaluation of epileptic patients with tuberous sclerosis complex

Kaibao Sun1,2, Jianfei Cui3, Zhongwei Chen1, Tao Jiang4, Zhentao Zuo1, Rong Xue1,2, Yan Zhuo1, Bo Wang1, Shuli Liang3, and Lin Chen1,2

1State Key Laboratory of Brain and Cognitive Science, Beijing MRI Center for Brain Research, Institute of Biophysics, Chinese Academy of Sciences, Beijing, People's Republic of China, 2University of Chinese Academy of Sciences, Beijing, People's Republic of China, 3Chinese PLA general hospital, Beijing, People's Republic of China, 4Beijing Tian Tan Hospital, Capital Medical University, Beijing, People's Republic of China

Tuberous sclerosis complex (TSC) is an autosomal dominant genetic disease. 90% of patients with TSC suffer from epilepsy and 50% of them become medicine intractable epilepsy. Epilepsy surgery is an important treatment. However, some focal epileptogenic lesions, essential for surgery, are not well identified by current routine imaging protocols at 3T. 7T MR imaging is assessed in this study to allow better characterization of lesion details and to detect abnormalities previously unseen on 3T MRI and scalp electroencephalogram (EEG). This is the first report of clinical application of 7T MRI for pediatric patients (older than 8 years) with TSC epilepsy.

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