Abstract #2584

Functional neuroimaging using dynamic radial 3D UTE pulse sequences

Codi Amir Gharagouzloo¹, Chao Ma¹, Eline E. Verwer¹, Joseph B. Mandeville², Chuan Huang^3,4, Srinivas Sridhar⁵, Georges El Fakhri¹, Dustin W. Wooten¹, and Marc D. Normandin¹

¹Gordon Center for Medical Imaging, Massachusetts General Hospital & Harvard Medical School, Boston, MA, United States, ²Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, United States, ³Radiology, Stony Brook University, Stony Brook, NY, United States, ⁴Psychiatry, Stony Brook University, Stoney Brook, NY, United States, ⁵Nanomedicine Science and Technology Center, Northeastern University, Boston, MA, United States

Functional MR neuroimaging is an essential tool for studying brain activity. Cerebral blood volume (CBV) is an important indicator of brain function, but measurements are typically qualitative or relative. Furthermore, warping and signal drift necessitate significant image pre-processing with standard EPI acquisition. In this work, we utilize a radial 3D UTE pulse sequence with optimized acquisition parameters determined from phantoms and modeling. Feasibility of dynamic UTE as a functional neuroimaging method is demonstrated in non-human primates receiving NBOH-2C-CN, a 5-HT_2A receptor agonist. CBV is measured dynamically throughout the whole brain and shown to agree well with an analogous EPI experiment.

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