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Abstract #2599

Estimation of Focused-Ultrasound Induced CNS Molecular Delivery via Dynamic Contrast-Enhanced Magnetic-Resonance Imaging

Wen Yen Chai1,2, Po Chun Chu3, Chih Hung Tasi2, Chung Yin Lin4, Hung Wei Yang5, Hsin Yi Lai6, and Hao Li Liu2

1Department of Diagnostic Radiology and Intervention, Chang-Gung Memorial Hospital, Taoyuan, Taiwan, 2Department of Electrical Engineering, Chang-Gung University, Taoyuan, Taiwan, 3Department of Research and Development, NaviFUS corp., Taipei, Taiwan, 4Medical Imaging Research Center, Institute for Radiological Research, Chang-Gung University/Chang-Gung Memorial Hospital, Taoyuan, Taiwan, 5Medical Science and Technology, National Sun Yat-Sen University, Kaohsiung, Taiwan, 6Institute of Neuroscience and Technology, Zhejiang University, Zhejiang, People's Republic of China

Focused ultrasound (FUS) exposure with presence of microbubbles can transiently open the blood-brain-barrier (BBB) at targeted brain tissues. The purpose of this study is to investigate the feasibility to employ DCE-MRI to predict and estimate molecular CNS penetration under various exposure conditions and molecular sizes. Our result showed high accuracy and successful (prediction discrepancy was limited to be less than 10%) to estimate molecular penetration of FUS-induced BBB opening via imaging index (Ktrans) from DCE-MRI. This approach may bring technology advances and facilities the clinical application of FUS-induced BBB opening to deliver therapeutic molecules for CNS disease treatment.

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