Abstract #2599

Estimation of Focused-Ultrasound Induced CNS Molecular Delivery via Dynamic Contrast-Enhanced Magnetic-Resonance Imaging

Wen Yen Chai^1,2, Po Chun Chu³, Chih Hung Tasi², Chung Yin Lin⁴, Hung Wei Yang⁵, Hsin Yi Lai⁶, and Hao Li Liu²

¹Department of Diagnostic Radiology and Intervention, Chang-Gung Memorial Hospital, Taoyuan, Taiwan, ²Department of Electrical Engineering, Chang-Gung University, Taoyuan, Taiwan, ³Department of Research and Development, NaviFUS corp., Taipei, Taiwan, ⁴Medical Imaging Research Center, Institute for Radiological Research, Chang-Gung University/Chang-Gung Memorial Hospital, Taoyuan, Taiwan, ⁵Medical Science and Technology, National Sun Yat-Sen University, Kaohsiung, Taiwan, ⁶Institute of Neuroscience and Technology, Zhejiang University, Zhejiang, People's Republic of China

Focused ultrasound (FUS) exposure with presence of microbubbles can transiently open the blood-brain-barrier (BBB) at targeted brain tissues. The purpose of this study is to investigate the feasibility to employ DCE-MRI to predict and estimate molecular CNS penetration under various exposure conditions and molecular sizes. Our result showed high accuracy and successful (prediction discrepancy was limited to be less than 10%) to estimate molecular penetration of FUS-induced BBB opening via imaging index (K_trans) from DCE-MRI. This approach may bring technology advances and facilities the clinical application of FUS-induced BBB opening to deliver therapeutic molecules for CNS disease treatment.

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