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Abstract #2732

Free Breathing Myocardial MOLLI T1 Mapping using Real-time Slice Tracking and Non-Rigid Image Registration

Céline Smekens1, Radhouene Neji1,2, Reza Razavi1, René Botnar1, and Sébastien Roujol1

1Division of Imaging Sciences and Biomedical Engineering, King's College London, London, United Kingdom, 2MR Research Collaborations, Siemens Healthcare Limited, Frimley, United Kingdom

The modified Look Locker (MOLLI) sequence is the most widely used myocardial T1 mapping approach. In this 2D sequence, several T1-weighted images are acquired within a breath hold and used to create a T1 map. However, some patients are unable to sustain stable breath-holds which generates 3D motion between the T1-weighted images. While image registration can potentially be used to correct for in-plane motion, through-plane motion cannot be corrected and may introduce bias in T1 estimates. In this study, we sought to develop and assess a free breathing MOLLI sequence with real-time slice tracking and non-rigid image registration to reduce in-plane and through-plane motion effects.

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