Abstract #2733

Off-resonance correction in myocardial T1-mapping using Bloch simulations of the MOLLI sequence

Nicola Martini¹, Andrea Barison², Maria Filomena Santarelli³, Daniele Della Latta¹, Francesco Avogliero¹, Vincenzo Positano², Luigi Landini², and Dante Chiappino¹

¹Fondazione Toscana "G. Monasterio", Massa, Italy, ²Fondazione Toscana "G. Monasterio", Pisa, Italy, ³CNR Institute of Clinical Physiology, Pisa

Myocardial T1 mapping using MOLLI is influenced by off-resonance effects that lead to underestimation of T1. In this study a method for the correction of the off-resonance influence on T1 mapping, based on the Bloch simulations of the MOLLI sequence, is proposed. In vivo results on a healthy population (N=67) showed that the regional variation of T1 is highly correlated with the distribution of the off-resonance. The proposed method effectively reduced the artifactual T1 underestimation due to off-resonance, especially in myocardial segments that exhibited elevated B0 inhomogeneities.

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