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Abstract #2733

Off-resonance correction in myocardial T1-mapping using Bloch simulations of the MOLLI sequence

Nicola Martini1, Andrea Barison2, Maria Filomena Santarelli3, Daniele Della Latta1, Francesco Avogliero1, Vincenzo Positano2, Luigi Landini2, and Dante Chiappino1

1Fondazione Toscana "G. Monasterio", Massa, Italy, 2Fondazione Toscana "G. Monasterio", Pisa, Italy, 3CNR Institute of Clinical Physiology, Pisa

Myocardial T1 mapping using MOLLI is influenced by off-resonance effects that lead to underestimation of T1. In this study a method for the correction of the off-resonance influence on T1 mapping, based on the Bloch simulations of the MOLLI sequence, is proposed. In vivo results on a healthy population (N=67) showed that the regional variation of T1 is highly correlated with the distribution of the off-resonance. The proposed method effectively reduced the artifactual T1 underestimation due to off-resonance, especially in myocardial segments that exhibited elevated B0 inhomogeneities.

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