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Abstract #2739

Non-contrast T1 mapping can detect myocardial fibrosis in hypertrophic cardiomyopathy without gadolinium. Is native T1 a superior alternative to late gadolinium enhancement?

Yoshiaki Morita1, Naoaki Yamada1, Teruo Noguchi2, Yoshiaki Watanabe1, Tatsuya Nishii1, Atsushi Kono1, and Tetsuya Fukuda1

1Department of Radiology, National Cerebral and Cardiovascular Center, Suita, Osaka, Japan, 2Division of Cardiology, National Cerebral and Cardiovascular Center, Suita, Osaka, Japan

Native T1 mapping is a novel cardiac magnetic resonance technique for myocardial tissue characterization without contrast administration. Native T1-mapping in hypertrophic cardiomyopathy was correlated with T1 map-based extracellular volume fraction, and native T1 of apparently late gadolinium enhancement (LGE)-negative segments were significantly longer than normal myocardium. Therefore, native T1 mapping has the potential to quantify the volume of interstitial space without gadolinium, which would be useful particularly in patients who are limited in use of gadolinium. Furthermore, native T1 would be a useful biomarker for the detection of diffuse myocardial damage difficult to evaluate using conventional LGE alone.

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