Intraplaque hemorrhage (IPH), a characteristic feature of high-risk atherosclerosis, can be identified as hyperintensity areas on T1-weighted MRI. Simultaneous Non-contrast Angiography and intraPlaque hemorrhage (SNAP) MRI has been shown to provide comparable IPH detection as MPRAGE with additional benefit of lumen assessment in the same scan. In this study, we developed a semi-automatic method to detect and quantify IPH on SNAP MRI with histology confirmation. An objective IPH detection threshold was identified and high scan-rescan reproducibility was obtained for semi-automatic IPH volume measurement and maximum IPH intensity.
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