Carotid plaque vasa vasorum angiogenesis from adventitia may be influenced by inflammation, could promote intraplaque hemorrhage and decrease the thickness of fibrous cap, finally, the cap is prone to rupture. Drug therapy and assessment to the vulnerable plaque, in vivo, would be of major clinical interest. To investigate whether lipid therapy leads to changes in vasa vasorum characteristics of carotid unstable plaque in chinese patients, as measured by using dynamic contrast-enhanced (DCE) MRI. Focus on inflammation to monitor the early beneficial therapy using vasa vasorum MR imaging, biomarker in vivo.
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