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Abstract #2785

Identification of Carotid Lipid-Rich Necrotic Core by Three-Dimensional Magnetization-Prepared Rapid Acquisition Gradient-Echo Imaging

Huiyu Qiao1, Dongxiang Xu2, Feiyu Li3, William S. Kerwin2, Lars Johansson4, Chun Yuan1,2, and Xihai Zhao1

1Center for Biomedical Imaging Research, Department of Biomedical Engineering, Tsinghua University, Beijing, People's Republic of China, 2Department of Radiology, University of Washington, Seattle, WA, 3Department of Radiology, Peking University First Hospital, Beijing, People's Republic of China, 4Department of Radiology, Uppsala University Hospital, Sweden

Carotid atherosclerotic lipid-rich necrotic core (LRNC) is associated with ischemic cerebrovascular events. Currently, LRNC was mainly characterized by contrast-enhanced T1 weighted (CE-T1W) or T2 weighted (T2W) imaging. However, CE-T1W imaging needs gadolinium application and T2W imaging is challenging to identify LRNCs with long-T2 components. This study investigated the usefulness of MP-RAGE in identifying carotid LRNC by comparing with CE-T1W and T2W imaging. We found that LRNC had the lowest relative signal intensity against muscle or fibrous tissue on MP-RAGE images among three sequences (P<0.05), indicating that MP-RAGE might be a better non-contrast imaging tool to identify LRNC than T2W imaging.

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