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Abstract #2830

A novel platform to study hemodynamics and morphology in an ex vivo carotid artery model under pulsatile flow conditions

Kristina Andelovic1, Patrick Winter2, Thomas Kampf2,3, Volker Herold2, Sebastian Schuerlein4, Jan Hansmann4, Peter Jakob2,5, and Wolfgang Bauer1

1Medizinische Klinik und Poliklinik I, Universitätsklinikum Würzburg, Würzburg, Germany, 2Experimentelle Physik V, Universität Würzburg, Würzburg, Germany, 3Institut für Diagnostische und Interventionelle Neuroradiologie, Universitätsklinikum Würzburg, Würzburg, Germany, 4Deptartment of Tissue Engineering and Regenerative Medicine, Universitätsklinikum Würzburg, Würzburg, Germany, 5Fraunhofer IIS, Fraunhofer EZRT, Magnetresonanz- und Röntgenbildgebung (MRB), Würzburg, Germany

Biological artery models, cultured in a bioreactor-platform with adjustable pulsatile flow conditions, represent a potential in vitro test system for atherosclerosis research and provide a suitable tool for the development of new flow quantification techniques as well as studies of arterial elasticity and flow dynamics ex vivo and in vitro. A major requirement for these studies is viable motion synchronization in order to achieve time-resolved flow measurements. We present a new platform that uses self-navigation instead of external trigger signals for measurements of 2D- and 4D flow dynamics, vessel wall morphology and quantifications of arterial pulse-wave-velocity and wall shear stress.

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